Thomas E Willnow Selected Research

sortilin

11/2020	VPS10P Domain Receptors: Sorting Out Brain Health and Disease.
12/2017	SORLA attenuates EphA4 signaling and amyloid β-induced neurodegeneration.
2/2016	Protein sorting gone wrong--VPS10P domain receptors in cardiovascular and metabolic diseases.
1/2016	SORLA facilitates insulin receptor signaling in adipocytes and exacerbates obesity.
12/2015	Role of Sortilin in Models of Autoimmune Neuroinflammation.
9/2014	Sorting receptor sortilin-a culprit in cardiovascular and neurological diseases.
1/2013	SorLA deficiency dissects amyloid pathology from tau and cholinergic neurodegeneration in a mouse model of Alzheimer's disease.
11/2012	The sorting receptor Sortilin exhibits a dual function in exocytic trafficking of interferon-γ and granzyme A in T cells.
9/2010	Sort1, encoded by the cardiovascular risk locus 1p13.3, is a regulator of hepatic lipoprotein export.
5/2008	Sortilin-related receptor with A-type repeats (SORLA) affects the amyloid precursor protein-dependent stimulation of ERK signaling and adult neurogenesis.

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Thomas E Willnow Research Topics

Disease

27	Alzheimer Disease (Alzheimer's Disease) 10/2021 - 09/2005
5	Obesity 05/2021 - 08/2009
4	Insulin Resistance 01/2020 - 01/2018
4	Amyloid Plaque 01/2013 - 09/2005
3	Neurodegenerative Diseases (Neurodegenerative Disease) 11/2020 - 01/2006
3	Huntington Disease (Huntington's Disease) 11/2019 - 12/2009
3	Hypercholesterolemia 02/2016 - 09/2010
3	Neoplasms (Cancer) 09/2014 - 10/2005
2	Donnai-Barrow syndrome 08/2021 - 01/2020
2	Stroke (Strokes) 01/2020 - 09/2014
2	Epilepsy (Aura) 11/2019 - 01/2019
2	Infections 01/2019 - 11/2012
2	Body Weight (Weight, Body) 12/2018 - 01/2018
2	Nephrocalcinosis 01/2018 - 08/2012
2	Holoprosencephaly (Arhinencephaly) 08/2017 - 01/2005
2	Fanconi Syndrome (Syndrome, Fanconi) 08/2017 - 01/2017
2	Atherosclerosis 02/2016 - 04/2011
1	Polycystic Ovary Syndrome (Syndrome, Stein-Leventhal) 01/2020
1	Ischemic Stroke 11/2019
1	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 11/2019
1	Chronic Disease (Chronic Diseases) 11/2019
1	Cerebellar Ataxia (Dysmetria) 11/2019
1	Virus Diseases (Viral Diseases) 01/2019
1	Hypercalciuria 01/2018
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2018
1	Glut1 Deficiency Syndrome 01/2018
1	Polyuria 01/2018
1	Autoimmune Diseases (Autoimmune Disease) 12/2015
1	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 12/2015
1	Multiple Sclerosis 12/2015
1	Inflammation (Inflammations) 12/2015
1	Neuroinflammatory Diseases 12/2015
1	Retinal Degeneration 09/2014
1	Spinal Cord Injuries (Spinal Cord Injury) 09/2014
1	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder) 06/2014
1	Neural Tube Defects (Exencephaly) 05/2014
1	Alzheimer Disease 10 01/2013
1	Colitis 11/2012
1	Dyslipidemias (Dyslipidemia) 04/2011
1	Cardiovascular Diseases (Cardiovascular Disease) 04/2011
1	Seizures (Absence Seizure) 03/2011
1	Tetany (Spasmophilia) 03/2011
1	Cardiac Arrhythmias (Arrythmia) 03/2011
1	Albuminuria 11/2010
1	Neurilemmoma (Schwannoma) 04/2010

Drug/Important Bio-Agent (IBA)

18	Proteins (Proteins, Gene)FDA Link 01/2018 - 09/2005
15	Amyloid (Amyloid Fibrils)IBA 01/2016 - 09/2005
12	sortilinIBA 11/2020 - 02/2007
10	Low Density Lipoprotein Receptor-Related Protein-2IBA 08/2021 - 02/2003
7	Peptides (Polypeptides)IBA 01/2018 - 04/2010
7	Amyloid beta-PeptidesIBA 01/2010 - 09/2005
4	Glucose (Dextrose)FDA LinkGeneric 01/2020 - 01/2016
3	LigandsIBA 08/2021 - 04/2010
2	LeptinIBA 05/2021 - 08/2009
2	LipidsIBA 01/2020 - 01/2018
2	Insulin (Novolin)FDA Link 01/2020 - 12/2018
2	Apolipoproteins E (ApoE)IBA 01/2020 - 01/2013
2	Insulin ReceptorIBA 01/2020 - 01/2016
2	ClusterinIBA 01/2020 - 01/2020
2	ApolipoproteinsIBA 01/2020 - 01/2013
2	claudin 10IBA 01/2018 - 08/2012
2	SodiumIBA 01/2018 - 08/2012
2	MagnesiumIBA 01/2018 - 03/2011
2	CalciumIBA 01/2018 - 02/2003
2	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 07/2013 - 06/2012
2	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/2013 - 12/2009
2	Lipoproteins (Lipoprotein)IBA 04/2011 - 09/2010
2	intrinsic factor-cobalamin receptorIBA 11/2010 - 02/2002
1	Apolipoprotein E3IBA 10/2021
1	Apolipoprotein E4IBA 10/2021
1	Pioglitazone (Actos)FDA Link 01/2020
1	EndostatinsIBA 01/2020
1	A-factor (Streptomyces)IBA 01/2020
1	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2020
1	Glutamic Acid (Glutamate)FDA Link 11/2019
1	Antiviral Agents (Antivirals)IBA 01/2019
1	Amino Acid Transport Systems (Amino Acid Transporter)IBA 01/2019
1	AntigensIBA 01/2019
1	Blood Glucose (Blood Sugar)IBA 12/2018
1	Facilitative Glucose Transport Proteins (Glucose Transporter)IBA 01/2018
1	claudin 16IBA 01/2018
1	PotassiumIBA 01/2018
1	NeuropeptidesIBA 01/2018
1	Amphetamine (Amfetamine)FDA LinkGeneric 06/2014
1	Folic Acid (Vitamin M)FDA LinkGeneric 05/2014
1	Low Density Lipoprotein Receptor-Related Protein-1 (LDL-Receptor Related Protein)IBA 05/2014
1	Nerve Growth Factor (NGF)IBA 01/2013
1	Cholinergic Agents (Cholinergics)IBA 01/2013
1	Presenilin-1IBA 01/2013
1	InterferonsIBA 11/2012
1	CytokinesIBA 11/2012
1	CationsIBA 08/2012
1	RNA (Ribonucleic Acid)IBA 03/2012
1	DNA (Deoxyribonucleic Acid)IBA 03/2012
1	AlbuminsIBA 11/2010
1	LDL Receptors (LDL Receptor)IBA 09/2010
1	EpitopesIBA 04/2010
1	Peptide Hormones (Polypeptide Hormones)IBA 08/2009
1	Immunotoxins (Immunotoxin)IBA 11/2008

Therapy/Procedure

1	Bone Marrow Transplantation (Transplantation, Bone Marrow) 01/2017